Exploration into conolidine has triggered discovery of an opioid receptor in the human body termed ACKR3/CXCR7. ACKR3 is apparently one of the most desired target for conolidine, which also disregards the opposite four classical opioid receptors(3). thanks.. A: There is proscribed info on contraindications involving Conolidine and blood thinners https://www.proleviate.com/post/conolidine-an-alternative-natural-pain-relief-to-replace-traditional-painkillers