Critically unwell individuals: Nitrous oxide inactivates methionine synthase by means of oxidation with the cobalt in vitamin B12 and will bring about megaloblastic anemia. This enzyme is essential for vitamin B12 and folate metabolism and performs a job in DNA and RNA synthesis as well as synthesis of other substances. https://dallasukapd.wikidirective.com/7763538/the_5_second_trick_for_nitrous_oxide_canisters