Below, we show that conolidine, a pure analgesic alkaloid Employed in classic Chinese drugs, targets ACKR3, therefore giving extra proof of the correlation concerning ACKR3 and ache modulation and opening substitute therapeutic avenues for the therapy of Long-term discomfort. The primary asymmetric overall synthesis of conolidine was developed by https://romaina024zzx5.wikirecognition.com/user