There exists a launch of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors inside the dorsal horn to decrease afferent discomfort transmission and produce analgesia. Hence, medicine like clonidine that goal alpha-two receptors can affect the transmission of ache. Clonidine is distributed in breast milk; caution https://bookmarkize.com/story19801869/the-2-minute-rule-for-onolidine