You will find there's launch of norepinephrine from your descending inhibitory bulbospinal neurons that binds to alpha-2-receptors within the dorsal horn to reduce afferent pain transmission and generate analgesia. Consequently, drugs like clonidine that target alpha-2 receptors can affect the transmission of suffering. Clonidine is distributed in breast milk; https://johnl849cag9.liberty-blog.com/profile