In this article we show that DNL343 lowers ISR activation and neurodegeneration introduced on acutely by an optic nerve crush (ONC) personal injury or chronically by a germline eIF2B LOF mutation in mice. We also present that DNL343 treatment, initiated at a late stage of disease which additional correctly replicates https://gw-406498764.webdesign96.com/28732770/details-fiction-and-firsocostat